Synthesis and Characterization of Impurities in the Production Process of Lopinavir.
نویسندگان
چکیده
Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances.
منابع مشابه
Synthesis, characterization and biocompatibility evaluation of hydroxyapatite - gelatin polyLactic acid ternary nanocomposite
Objective(s): The current study reports the production and biocompatibility evaluation of a ternary nanocomposite consisting of HA, PLA, and gelatin for biomedical application.Materials and Methods: Hydroxyapatite nanopowder (HA: Ca10(PO4)6(OH)2) was produced by burning the bovine cortical bone within the temperature range of 350-450 oC followed by heating in an oven at 800. Synthesis of the te...
متن کاملSynthesis and characterization of Cu nanoparticles and studying of their catalytic properties
In this paper, we report on the synthesis of Cu nanoparticles through a single-precursor route by controlling the growth temperature. Selective adsorption of oleylamine on various crystal planes may play an important role in the growth process. The understanding of this self-assembling process will help us develop reliable and reproducible methods to synthesis other three dimensional nanostruct...
متن کاملSynthesis and characterization of Cu nanoparticles and studying of their catalytic properties
In this paper, we report on the synthesis of Cu nanoparticles through a single-precursor route by controlling the growth temperature. Selective adsorption of oleylamine on various crystal planes may play an important role in the growth process. The understanding of this self-assembling process will help us develop reliable and reproducible methods to synthesis other three dimensional nanostruct...
متن کاملRemoval of Impurities fromWaste Oil by Combination of Eggshell and Eggshell's active Carbon for Biodiesel Production
Waste oil is an inexpensive source for biodiesel production, but the high amount of impurities present (free fatty acids, oxidation products) impedes its practical application. The aim of this work is to assess the purification efficiency of the adsorption process with eggshell and its active carbon. Carbonization of eggshell was done at 200 ºC for 4 hours. For activation of the resultant carbo...
متن کاملSynthesis and Characterization of Graphene Oxide Nanoparticles and investigation of Nanofluid Application in Machining Process
The quality of machined workpieces, particularly precious metals, is the main goal of every machining process. A suitable cutting fluid can substantially affect the machining outcome. The study is novel in that it uses nanofluids in the machining process to mitigate the adverse effects of high temperatures and friction. Graphene oxide (GO) nanoparticles were synthesized using the modified Humme...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Scientia pharmaceutica
دوره 83 1 شماره
صفحات -
تاریخ انتشار 2015